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Political Power Boosts Controversial Green Energy Financing Scheme
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There are approximately 400,000 people with Tourette syndrome in the United States. About INGREZZA VMAT2 is a protein concentrated in the human brain that is primarily responsible for re-packaging and transporting monoamines (dopamine, norepinephrine, serotonin, and histamine) in pre-synaptic neurons. INGREZZA (valbenazine or NBI-98854), developed in the Neurocrine laboratories, is a novel, highly-selective VMAT2 inhibitor that modulates dopamine release during nerve communication, showing little or no affinity for VMAT1, other receptors, transporters and ion channels. INGREZZA is designed to provide low, sustained, plasma and brain concentrations of active drug to allow for once daily dosing. The proprietary name INGREZZA has been conditionally accepted by the U.S. Food and Drug Administration (FDA). Modulation of neuronal dopamine levels in diseases such as tardive dyskinesia, Tourette syndrome, Huntington's chorea, schizophrenia, and tardive dystonia, which are characterized, in part, by a hyperdopaminergic state, may provide symptomatic benefits for patients with these diseases. The Company has a pending New Drug Application (NDA) under review by the FDA to utilize INGREZZA for the treatment of tardive dyskinesia. The Company also has another ongoing placebo-controlled Phase II Tourette syndrome study evaluating INGREZZA in pediatrics, the T-Force GREEN study.
For the original version including any supplementary images or video, visit http://www.marketwatch.com/story/neurocrine-announces-completion-of-phase-ii-clinical-study-of-vmat2-inhibitor-ingrezzatm-valbenazine-in-adults-with-tourette-syndrome-2017-01-17